Research: My research uses computational methods to understand how the host immune response manifests within the central nervous system during HIV-associated tuberculous meningitis. Building on my work that identified CNS cytokine signatures associated with patient mortality, I am now applying multi-omic approaches to examine immune activity across CNS compartments. My goal is to define the immune features that distinguish different forms of TB meningitis and to understand how HIV-associated immunosuppression shapes the biology of CNS infection, ultimately to inform strategies aimed at improving patient outcomes.
Publications:
Wilt, Anna L et al. “Cerebrospinal Fluid Hypo-inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis.” The Journal of Infectious Diseases vol. 233,4 (2026): 787-798. doi:10.1093/infdis/jiag032
